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Collectively, these findings elucidate the molecular mechanisms underlying LPS-mediated HF pathogenesis, providing critical insights into the role of gut microbiotahost interactions in cardiovascular disease and establishing a foundation for targeted therapeutic strategies

Krivic et al., 2008

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and (4) metformin is safe, well-tolerated and cost-effective, making it an attractive addition to a cytotoxic therapeutic regimen, and it can be administered orally alongside infusional 5FU